Researchers from the University of Oxford and King’s College London have discovered the regulatory influence of a gene called KLF14 on other genes found within fat cells in the body. KLF14 has long been linked to metabolic conditions and cholesterol levels, but it was unknown as to what purpose it served. The study is published in the journal Nature Genetics.

What makes KLF14 special is that it controls the behavior of other important genes in fat cells that are associated with body-mass index, insulin, glucose levels and cholesterol. “KLF14 seems to act as a master switch controlling processes that connect changes in the behavior of subcutaneous fat to disturbances in the muscle and liver…” said Mark McCarthy, from Oxford University.

The researchers examined over 20,000 genes found in fat samples from 800 female twin volunteers in the UK. They found an association between the KLF14 gene and the behavior of multiple distant genes, demonstrating its ability to influence and regulate other genes that reside in fat cells. The same results were seen in unrelated samples from 600 Icelandic subjects. The study confirms that KLF14 behaves as a regulator of many metabolic traits.

Professor Tim Spector from King’s University commented, “This is the first major study that shows how small changes in one master regulator gene can cause a cascade of other metabolic effects in other genes.” This complex interrelationship between genes is just beginning to be understood by science, but natural medicine has been using these principles since ancient times. Many botanicals, herbs and nutrients “communicate” with our bodies on a cellular level and influence genetic expression and our DNA specifically to promote health and balance.

Today, 1 in 10 adults worldwide is significantly overweight, and many more struggle with abnormal metabolic conditions due to poor diet and minimal physical activity. Reducing the amount of processed food you eat and implementing an exercise routine into your lifestyle is a key part of losing weight. However, as our individual genetics dictate, not everyone loses weight at the same speed, and many of us face challenging triggers and food cravings that hinder our weight loss goals.

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A critical component in the formula is an alginate complex derived from kelp, which effectively reduces the uptake of cholesterol and glucose. Alpha-lipoic acid, L-Taurine, and Gymnema leaf are included due to their ability to increase insulin sensitivity on a cellular level. Chromium is included based on research showing its role in regulation of insulin and for its effects on carbohydrate, protein and fat metabolism.

Along with a nutritious diet and regular exercise, Integrative Metabolic Formula can put you on the right path to metabolic wellness by helping to balance your body’s blueprint for a healthymetabolism and increased vitality, naturally.

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